Schizophrenia, weight gain and atypical antipsychotics
نویسندگان
چکیده
منابع مشابه
Atypical antipsychotics in the treatment of schizophrenia.
Over the last few years atypical antipsychotics have been used increasingly in the pharmacological treatment of schizophrenia. This review provides an overview of the pharmacological and clinical characteristics of atypical antipsychotics. In particular we discuss their efficacy in treating psychotic and negative symptoms as well as treatment-refractory patients. The most important side effects...
متن کاملNew atypical antipsychotics for schizophrenia: iloperidone
The optimal treatment of schizophrenia poses a challenge to develop more effective treatments and safer drugs, to overcome poor compliance, discontinuation and frequent switching with available antipsychotics. Iloperidone is a new dopamine type 2/serotonin type 2A (D(2)/5-HT(2A)) antagonist structurally related to risperidone, expected to give better efficacy with less extrapyramidal symptoms t...
متن کاملRecent evidence and potential mechanisms underlying weight gain and insulin resistance due to atypical antipsychotics.
OBJECTIVE Atypical antipsychotics (AAPs) promote obesity and insulin resistance. In this regard, the main objective of this study was to present potential mechanisms and evidence concerning side effects of atypical antipsychotics in humans and rodents. METHOD A systematic review of the literature was performed using the MEDLINE database. We checked the references of selected articles, review ...
متن کاملWeight Gain, Schizophrenia and Antipsychotics: New Findings from Animal Model and Pharmacogenomic Studies
Excess body weight is one of the most common physical health problems among patients with schizophrenia that increases the risk for many medical problems, including type 2 diabetes mellitus, coronary heart disease, osteoarthritis, and hypertension, and accounts in part for 20% shorter life expectancy than in general population. Among patients with severe mental illness, obesity can be attribute...
متن کاملAcute weight gain, gender, and therapeutic response to antipsychotics in the treatment of patients with schizophrenia
BACKGROUND Previous research indicated that women are more vulnerable than men to adverse psychological consequences of weight gain. Other research has suggested that weight gain experienced during antipsychotic therapy may also psychologically impact women more negatively. This study assessed the impact of acute treatment-emergent weight gain on clinical and functional outcomes of patients wit...
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ژورنال
عنوان ژورنال: The British Journal of Psychiatry
سال: 2006
ISSN: 0007-1250
DOI: 10.1192/bjp.188.2.191-b